ABSTRACT
Objective To investigate the effect of celecoxib on serum biochemical parameters in rheumatoid arthritis patients and its clinical effect and safety assessment.Methods 92 cases of rheumatic arthritis were selected and divided into two groups.46 cases in control group were treated with methotrexate and hydroxychloroquine sulfate, and 46 cases in experitment group were treated on the basis of control group with celecoxib.The serum osteoprotegerin ( OPG) levels and related biochemical parameters, efficacy evaluation by doctors and self evaluation of patients and adverse reactions were compared between two groups.Results After treatment, the serum levels of IL-1, IL-6, CRP, C3, C4, RF, IgA, IgG and IgM levels after treatment were significantly lower than those before treatment in two groups ( P <0.05 ) , OPG serum level after treatment group was lower than that before treatment in experiment group ( P <0.05 ) , but there was no significant difference in control group.The above indexes in experiment group in experiment group were lower than those in control group after treatment.The efficacy evaluation by doctors in experiment group was 86.96%, which was higher than 69.57% in control group(χ2 =4.09,P<0.05), and efficacy self evaluation by patients was 84.78%, which was higher than 65.22% in control group (χ2 =4.70,P<0.05).The adverse reactions in experiment group was 13.04%, which was significantly lower than 45.56% in control group (χ2 =11.79,P<0.01).Conclusion Celecoxib could significantly improve clinical symptoms and physical sign and serum biochemical markers, and reduce adverse reactions in rheumatoid arthritis patients, which is an effective and safety treatment.